The University of Antioquia, also called UdeA, is primarily a public research-based university, located in the city of Medellín, Colombia. With regional campuses in Amalfi, Andes, Caucasia, Carmen de Viboral, Envigado, Puerto Berrío, Santa Fe de Antioquia, Segovia, Sonsón, Turbo and Yarumal, it remain one of the oldest university in the region. As of 2024, we can read on their publication site that, more than 272 groups and over 5,000 faculty students, are working on 1,200 collaborative projects. Founded in 1803 after a Royal Decree was issued by King Charles IV of Spain, under the name Franciscan College, they have maintained their accreditation from the Ministry of Education for more than 2 centuries.

. Along with the University of the Andes, each institution hold the second longest term behind the National University of Colombia. UdeA and the Tecnológico de Antioquia have the largest number of seats in the department of Antioquia.